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Having two wheelsets of the same size to extend the field of application for a given bike is not a bad idea if one doesn't want to go through the hassle of changing tires.
Having tow different sized wheelsets for the same bike under the precondition that both the brake system and the frame size allow for it, may or may not work. It *will* affect geometry and handling, some frames may deal with that better than others.
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Jeremy Clarksons bike-riding cousin
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