Have personally never had much luck with lightweight/low spoke handbuilts.
I guess it depends alot on your weight, although I'm not particularly heavy. The best handbuilts I've owned have all had 28 spokes or more, with 2/1.8/2 spokes on the rear driveside minimum. The light weight wheels have never ridden as well.
If you've got the budget, I guess you could spec a few more spokes and spend a load on some Extalite hubs to keep the weight down.
IMO you're better off just going for something in the 1550-1650g range and buying a carbon seatpost/saddle/handlerbars etc. (of course you may already have these :-D )
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