Absolutely. My fatbike gets 650b 2.6 in the summer, my gravel bike has 2 wheel sets. (650&700), my son’s now-too-small Diamondback 650c also ran 26” cx wheels. Worst case scenario is a few minutes with a 5mm Allen adjusting brakes, best case is matching hubs and rotors. Having different wheels for a single frame is really great and allows the bike to change personality.
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