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I just bought these to replace a 6700 compact with 46 large that got called to duty on another bike. I had thought these new GRX were 10 speed box has the "2x11" box checked rather than the "2x10". We will see how it works with 10 sp. Or I can just use an 11sp chain. As far as fd goes, I am not beyond bending 9 and 10 speed cages to get them to work, limit screw is a different story though. We will see.
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