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I have both set-ups. On my old Bob Jackson I have a 10s STI 105 triple shifter set with a 12-30 cassette and a 48-36-24 triple. Shifts fine. On my Anderson, I wanted STI hydro, so that's a 2x11. 44-33 front, and for D2R2 it's got a 11-40 cassette (R8000 Ultegra RD with a Wolftooth DM link). Lowest and highest gears similar, larger jumps on the 2x11 cassette. Normally that bike wears a 12-34 cassette, fine for Martha's Vineyard's paltry hills.
My Litespeed Unicoi drop bar conversion usually has the 11-40 and DM link, 11s Shimano hydro shifters just like the Anderson, but a 42-28 front gives a 18.4 inch low gear, because that bike gets both single track and pavement mixed duty. It's set up to get all 11 cogs on the 42T chainring.
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