I've got a 20" rear wheel on my cargo bike with a 2.15" tire and am not sure you could fit anything larger than 34t cassette in the rear unless you go with the Microshift Advent Super Short (38t). Derailleur would hit the ground. I assume most 1x12 stuff is going to have a huge cassette and would be too big.
Also don't forget you need a larger chainring for such a small rear wheel.
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