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Not exactly sure how much help I can be because all my major business travel was many years ago prior to the advent of the 4wheel rolling bags. But back then I too traveled for business pretty much exclusively with a backpack. It was a good sized backpack that was designed to carry my 17" laptop in a virtical sleeve. I could easily carry 2'ish days clothes with a change of shoes included. Creative folding helped and was needed to mitigate wrinkles and as much need for ironing. I liked this method for 2 main reasons: 1) Everything was together [laptop & business items, along with my clothes], 2) The main reason was that I valued mobility. I was regularly going places I'd never been and wanted to be efficient and swift. I NEVER checked anything and I could easily move through the airport crowds, get on a bus or subway, and also be less of 'a problem' when traveling with co-workers. Some of the crap they traveled with boggled the mind.
Cheers,
CJB
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