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The GRX shifter are great for folks with larger hands and there are thumb buttons that allow etap-style shifts when you're tucked down (left goes up, right goes down - in the rear). The RD is not as smooth though as a RX805 or Ultegra Di2. My perfect setup for all-road would be a 32/48 up front, 11-36 SRAM in the rear, GRX Di2 shifters, Ultegra Di2 FD, and RX805 RD.
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