thwart
07-22-2020, 11:41 AM
From the journal Science (Horowitz AM et al. Science 2020 Jul 10):
In both animals and humans, regular exercise improves neurogenesis and cognition. Transfer of blood from young mice to old mice also improves neurogenesis and cognition, which suggests that such improvements are mediated by specific molecules. Might benefits of exercise on the aging brain be conferred by such molecules?
A series of experiments demonstrated several things:
In older mice, regular exercise, compared with sedentary behavior, improved neurogenesis, learning ability, and memory.
Blood extracted from older, midlife, or younger exercising mice that was injected intravenously into older sedentary mice produced improved neurogenesis, learning ability, and memory; blood infusions from sedentary mice did not have this effect.
Mass spectrometry identified about 30 molecules that increased following exercise; one of the most prominent was Gpld1, a molecule produced by the liver and not linked previously to aging or neurogenesis. When researchers enhanced liver production of Gpld1, it led to improved neurogenesis and cognition. Levels of Gpld1 also are higher in physically active (i.e., >7100 steps/day) humans than in sedentary humans.
Well, there you go. Just park your bike, sit down and schedule an infusion.
;)
In both animals and humans, regular exercise improves neurogenesis and cognition. Transfer of blood from young mice to old mice also improves neurogenesis and cognition, which suggests that such improvements are mediated by specific molecules. Might benefits of exercise on the aging brain be conferred by such molecules?
A series of experiments demonstrated several things:
In older mice, regular exercise, compared with sedentary behavior, improved neurogenesis, learning ability, and memory.
Blood extracted from older, midlife, or younger exercising mice that was injected intravenously into older sedentary mice produced improved neurogenesis, learning ability, and memory; blood infusions from sedentary mice did not have this effect.
Mass spectrometry identified about 30 molecules that increased following exercise; one of the most prominent was Gpld1, a molecule produced by the liver and not linked previously to aging or neurogenesis. When researchers enhanced liver production of Gpld1, it led to improved neurogenesis and cognition. Levels of Gpld1 also are higher in physically active (i.e., >7100 steps/day) humans than in sedentary humans.
Well, there you go. Just park your bike, sit down and schedule an infusion.
;)