Specifically 583 is narrow with almost no shoulder in many places. If you ride late morning, the commuters are off the roads and it's locals who tend to drive slower and will simply go along behind you until they can safely pass or you pull off. But rush hours are a different story, as is lunchtime. There are lots of riders but while the majority of drivers are careful and patient, there's always someone who tries to cut around because he's already sat behind a dozen other riders and he'll shoot ahead and suddenly be in your face as he comes around a curve. There are stone blocks on one side and typically stone cliffs on the other side. Road width is a bit irregular and the blocks are right up against the pavement so you have absolutely nowhere to go if you have to dodge somebody.
The roads up into the hills are much nicer. The Ghisallo is iconic and the road up and over is great to climb. The descent should be taken carefully -- there are lots of cars parked and cars pulling onto the roadway. You can't take it down like you can descend Canyon Road -- bad sight lines and too many surprises. There are lots of little back routes that give you some very steep little rises and all kinds of scenery. Don't ride those roads like you'd ride one of the big cols, don't try to become a Strava king, and keep your eyes open. Absolutely don't ride into the evening, even with lights, because sight lines often aren't long enough for someone to respond to a light.
Personally, I'd hike all over the place and leave the bike at home.
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