OT: Backpack for business travel

[C40_guy]

My business travel is picking up a bit, mostly 2-3 days. I need to carry business casual and I'm pretty good at packing. (I carry a lot...but pack well. I am by no means a minimalist)

I've used a Tom Bihn suitcase in the past and like the wheels-free mobility.

I'm thinking that perhaps a traditional backpack might be something to try.

Have others done multiday business travel with a backpack?

What are the benefits/drawbacks of this approach? What makes life easier? Packing cubes? Many small pockets? One large duffel style opening?

...traditional hiking backpack like the Osprey below, or something like the Patagonia Black Hole MLC pack that seems to be more like a suitcase with straps? Or...the Tom Bihn Aeronaut 45?

Assuming that this bag gets put into the overhead, what's your secondary bag? Mine is a midsize backpack that holds laptop, Bose headphones, snack food, etc. I don't expect to be carrying *two* backpacks...

Do I take a *smaller* bag out of the backpack for the trip?

My next trip is transcon - BOS-SEA - in two weeks, two day conference plus red-eye back...

Osprey Kestrel 48 shown for consideration (just picked it off the REI website...seems like a good volume...