I have that much clearance (or less) at the front brake caliper on the Oltre. Probably >5 at frame intersections, so not much concern over rub/frame damage, even for out of the saddle climbs/efforts. The worst of it is occasional mud gather on the caliper, which prompts me to stop and clear it with a stick. Ive been using this setup for a year with very little trouble, but that's in a SW climate. I recommend giving it a try.
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