I just built up a new bike with DA 9100 mechanical after using Di2 exclusively for three years. IMO Di2 is a "nice to have," not a "have to have."
With Di2 you gain:
Precise shifts, every single time
No cable stretch to worry about
The ability to fine tune shifting on the fly via the junction box and shift paddles
Rapid-fire downshifts and upshifts. You can dump an entire cassette very quickly just by holding the button down.
Clean lines without shifting cables running down your downtube
Potential downsides:
You lose a lot of the tactile feel that many of us enjoy
If you're a traditionalist, you obviously lose that aesthetic when going electronic
Your wallet gets lighter
Definitely not a major pain point since it is so infrequent, but you do have to remember to charge the battery
If it's in your budget, I say definitely go for it. But like I said above, IMO it's a "nice to have" and not a "have to have."
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